Hepatitis B surface antigen immunopurification using a plant - derived specific antibody coupled to Sepharose CL - 4 B at different ligand densities
نویسندگان
چکیده
Hepatitis B surface antigen immunopurification using a plant-derived specific antibody coupled to Sepharose CL-4B at different ligand densities Rodolfo Valdés, Yenisley Medina, William Ferro, José A. Montero, Tatiana Alvarez, Déborah Geada, Alberto Leyva, Leonardo Gómez, Sigifredo Padilla, Biunayki Reyes, Leonardo Pacín, Alejandro Figueroa, Andrés Tamayo, Lorely Milá, Yurisleydi Aldama and María del Carmen Abrahantes Monoclonal Antibody Production Department, Process Control Department, Quality Control Direction, Process Development Direction. Center for Genetic Engineering and Biotechnology. P.O. Box 6162, Havana 10600, Cuba Tobacco Research Institute. Aguiar #360 be/ Obispo and Obrapía. Havana 10100, Cuba
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Priming Hepatitis B Surface (HBsAg)- and Core Antigen (HBcAg)-Specific Immune Responses by Chimeric, HBcAg with a HBsAg ‘a’ Determinant
We developed an immunogen to stimulate multivalent immunity against hepatitis B surface antigen (HBsAg) and hepatitis B core antigens (HBcAg). Immune responses specific for both HBsAg and HBcAg play an important role in controlling the infection. HBsAg-specific antibodies mediate elimination of virions at an early stage of infection and prevent the spread of virus. The immunogen was constructed...
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